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Bed Rest Worsens Impairments in Fat and Glucose Metabolism in Older, Overweight Adults.
|Title||Bed Rest Worsens Impairments in Fat and Glucose Metabolism in Older, Overweight Adults.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Coker, RH, Hays, NP, Williams, RH, Xu, L, Wolfe, RR, Evans, WILLIAMJ|
|Journal||J Gerontol A Biol Sci Med Sci|
|Date Published||2013 Jul 31|
BACKGROUND: The effects of bed rest on the dysregulation of fatty acid and glucose metabolism have not been addressed in the older population.
OBJECTIVE: We examined the effect of 10 days of bed rest on fatty acid kinetics and hepatic and peripheral insulin resistance in aging.
METHODS: We utilized an octreotide, basal glucagon replacement, multistage insulin infusion, and the concomitant infusion of [6,6 (2)H2]glucose to derive insulin-mediated suppression of glucose production and insulin-stimulated glucose disposal in nine older, overweight individuals (body mass index 28.1 ± 1.7 kg m(-2); 39.9% ± 1.9% fat). During the multistage insulin infusion, we also infused [1-(13)C]palmitate to examine free fatty acid rate of appearance (R a).
RESULTS: Body weight, % body fat, and energy metabolism did not change with bed rest. There was a significant decrease (-2291 ± 316cm(3)) in visceral fat, and no change in abdominal subcutaneous fat with bed rest. Insulin-mediated suppression of glucose production was modest prior to bed rest and was further reduced (>15% ± 2%) by bed rest. There was also a minor decrease in the insulin-mediated suppression of free fatty acid R a after bed rest and, as a consequence, a small variation in plasma free fatty acid from pre- to post-bed rest in the first stage of the multistage insulin infusion. There was also a significant bed rest-induced decline (>2.0 ± 0.6 mg kg FFM(-1) min(-) (1)) in insulin-stimulated glucose disposal.
CONCLUSIONS: Preexisting impairments in insulin sensitivity are worsened by bed rest and seem linked to alterations in the regulation of free fatty acid in older, overweight individuals.
|Alternate Journal||J. Gerontol. A Biol. Sci. Med. Sci.|