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CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people.

TitleCDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people.
Publication TypeJournal Article
Year of Publication2014
AuthorsKlimentidis, YC, Lemas, DJ, Wiener, HH, O'Brien, DM, Havel, PJ, Stanhope, KL, Hopkins, SE, Tiwari, HK, Boyer, BB
JournalJ Diabetes
Volume6
Issue3
Pagination251-9
Date Published2014 May
ISSN1753-0407
Abstract

BACKGROUND: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D), mainly among individuals of European ancestry. In the present study, we examined the frequency of these SNPs and their association with T2D-related traits in an Alaska Native study population with a historically low prevalence of T2D. We also investigated whether dietary characteristics that may protect against T2D, such as n-3 polyunsaturated fatty acid (PUFA) intake, modify these associations.

METHODS: In 1144 Yup'ik people, we examined 17 SNPs repeatedly identified in GWAS for individual and cumulative associations with T2D-related traits. Cumulative associations were evaluated using a genetic risk score (GRS) calculated by summing risk alleles. Associations were tested for interactions with sex, body mass index (BMI), and n-3 PUFA intake.

RESULTS: The rs7754840 SNP in CDKAL1 is significantly associated with HbA1c (P = 0.00091). The rs5015480 SNP near HHEX is significantly associated (in opposite direction to that in Europeans) with a combined fasting glucose (FG) and HbA1c measure (P = 0.00046) and with homeostatic model assessment of β-cell function (HOMA-B; P = 0.0014). The GRS is significantly associated with FG and combined FG and HbA1c only when the HHEX SNP is dropped from the GRS. Associations are not modified by BMI or n-3 PUFA intake.

CONCLUSION: Our results highlight the potential importance of CDKAL1 and HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of T2D, and suggest that these loci should be examined in greater detail in this population.

DOI10.1111/1753-0407.12093
Alternate JournalJ Diabetes
PubMed ID24112421
PubMed Central IDPMC3964139
Grant ListK01 DK095032 / DK / NIDDK NIH HHS / United States
P20 RR016430 / RR / NCRR NIH HHS / United States
P20RR016430 / RR / NCRR NIH HHS / United States
P30 GM103325 / GM / NIGMS NIH HHS / United States
R01 DK074842 / DK / NIDDK NIH HHS / United States
R01 DK074842 / DK / NIDDK NIH HHS / United States
R01-DKO74842-02S1 / / PHS HHS / United States
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