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Meal Replacement with Unique Essential Amino Acid Profile Promotes Superior Net Protein Balance

TitleMeal Replacement with Unique Essential Amino Acid Profile Promotes Superior Net Protein Balance
Publication TypeJournal Article
Year of PublicationSubmitted
AuthorsCoker, RH, Shin, K, Scholten, K, Johannsen, M, Kim, I-Y, Schutzler, SE, Tsigonis, J, Wolfe, RR
JournalClinical Nutrition
Abstract

Abstract: Background and Aims: Older individuals are susceptible to the
loss of muscle and accumulation of fat. To address this problem, we have
compared protein kinetics following consumption of an essential amino
acid (EAA)-enriched meal replacement (EMR) to consumption of a highprotein
meal replacement beverage (Bariatric Advantage, BA) using stable
isotope methodology.
Methods: Eight older (67±2), obese (35±2 kg/m2) participants completed
two studies using a randomized, crossover design in which they ingested
each meal replacement. The isotopic tracers L-[2H5]phenylalanine & L-
[2H2]tyrosine were delivered via primed, continuous intravenous infusion
throughout a basal period and following consumption of EMR or BA. We
determined whole body protein synthesis (PS), protein breakdown (PB), and
net protein balance (NB) via analysis of plasma samples by LC-ESI-MS.
Results: PS was higher (P=0.03) and PB was less (P=0.005) with EMR in
comparison to BA. As a result, NB was much greater (P=0.00003) following
the ingestion of EMR as compared to BA.
Conclusions: In comparison with BA, which has a higher amount of intact
protein that any other meal replacement, EMR promoted a greater increment
in NB. These data support the potential efficacy of EMR as a meal
replacement for the preservation of muscle during weight loss in older,
overweight individuals.

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