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The protonmotive force and respiratory control : 2 Building blocks of mitochondrial physiology

TitleThe protonmotive force and respiratory control : 2 Building blocks of mitochondrial physiology
Publication TypeManuscript
Year of Publication2017
AuthorsE, G, B, A, MG, A, F, A, E, AFrostner, M, B, DA, B, -Shachar, B, D, B, A, B, GC, B, RA, B, GR, B, Z, C, AJ, C, PM, C, JL, C, L, C, MS, D, T, D, G, D, C, D, J, E, E, E, A, F, J, F, LF, G-R, ML, G, H, G, BH, G, TA, G, J, H, DK, H, KT, H, P, H, O, H, CL, H, J, I-G, BA, I, S, I, P, J-D, NR, J, RK, J, T, K, DA, K, L, K, J, K, T, K, N, KJakovljevi, J, K, M, L-W, N, L, V, L, HK, L, H, L, J, L, E, L, LA, MM-C, M, M-K, AT, M, N, M, AJA, M, D, M, AL, M, AJ, M, S, N, K, N, D, O'G, PF, O, PF, O, Z, O, YK, P, CM, P, HH, P, D, P, PX, P, N, P, S, P, RK, P, F, P, EV, P, F, R, P, R, K, R-S, MM, R, J, R, GV, R, HB, R, D, S, R, S, M, S, M, S-K, JM, S, U, S, P, S, GR, S, D, S, O, S, M, S, R, S, Z, S, P, S, M, T, B, T, K, T, D, T, A, T, C, T, KJ, T, DJ, T, B, V, M, V, AE, V, VM, V, ML, W, C, W, YH, W, MR, W, M, W, J, W, RCI, W, M, Z, A, Z
Secondary AuthorsO, A, DM, B, BM, B, J, BFerreira, P, B, HE, B, E, B, V, B, J, B, E, C, JA, C, E, C, B, C, E, C, RH, C, A, C, AM, D, C, DPalma, H, D, MR, D, WJ, D, SE, D, AB, E, M, F, Z, G, KD, G, A, G, CW, G, C, G, CB, H, J, H, J, H, SC, H, RT, H, AJ, H, F, H, H, K, G, K, AV, K, M, K, WJH, K, AJ, K, A, K, G, L, A, M, M, M, JP, M, MA, M, A, M, J, M, DM, M, J, N, MT, O, ML, P, N, P, IKN, P, T, P, DM, R, K, S, C, S, LA, S, K, S, AM, S, R, S, BT, S, FAA, S, I, S, VK, S, P, S, A, S, RH, S, I, S, A, T, JP, T, L, T, IP, T, A, V, DM, V, C, W, K, Z
Collection TitleMitoEAGLE PrePrint
Date Published10/2017

Clarity of concept and consistency of nomenclature are key trademarks of a research field. These  trademarks   facilitate   effective  transdisciplinary  communication,  education,  and ultimately  further  discovery.  As  the knowledge base  and  importance  of  mitochondrial physiology to human health expand, the necessity for harmonizing nomenclature concerning mitochondrial respiratory states and rates has become increasingly apparent. Peter Mitchell’s concept  of  the  protonmotive  force  establishes  the  links  between  electrical  and  chemical components of energy transformation and coupling in oxidative phosphorylation. This unifying concept provides the framework for developing a consistent nomenclature for mitochondrial physiology and bioenergetics.  Herein, we follow  IUPAC  guidelines  on  general  terms  of physical chemistry, extended by the concepts of open systems and irreversible thermodynamics. We align the nomenclature of classical bioenergetics on respiratory states with a concept-driven constructive terminology to address the meaning of each respiratory state. Furthermore, we suggest uniform standards for the evaluation of respiratory states that will ultimately support the development of databases of mitochondrial respiratory function in species, tissues and cells studied under diverse physiological and experimental conditions. In this position statement, in the frame of COST Action CA15203 MitoEAGLE, we endeavour to provide a balanced view on mitochondrial respiratory control, a fundamental introductory presentation of the concept of the protonmotive force, and a critical discussion on reporting data of mitochondrial respiration.


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